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根据NHANES,评估平均体质体积作为妊娠维生素B12缺乏症查工具

Ülgen S Fideli¹, Ann I Scher¹, Cara Olsen¹

¹Department of Preventive Medicine and Biostatistics, F. Edward Hérbert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.

International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition

|July 20, 2023

概括

平均体积 (MCV) 可以有效地选孕妇的维生素B12缺乏. 这种廉价的测试可以识别异常的甲基马龙酸 (MMA) 水平,并有可能预防新生儿的神经缺陷.

科学领域:

临床生物化学临床生物化学
营养科学营养科学
血液学血液学血液学

背景情况:

维生素B12缺乏会导致不可逆转的神经损伤.
血清甲基马龙酸 (MMA) 和血总同型半氨酸 (tHCY) 是B12或叶酸缺乏症的敏感生物标志物.
早期发现维生素B12缺乏非常重要,尤其是在怀孕期间.

研究的目的:

评估平均体积 (MCV) 是否是异常MMA和tHCY水平的敏感指标.
为了确定最佳的MCV切割值来识别维生素B12缺乏症.
评估MCV作为查维生素B12异常的工具的实用性.

主要方法:

分析了来自26,397名参与者的NHANES数据.
权重线性和逻辑回归来评估MCV,MMA和tHCY之间的关联.
接收器运行曲线 (ROC) 分析和尤登指数以确定最佳的MCV切割值.

主要成果:

在一般人群 (18-85岁) 中,MCV和MMA/tHCY之间发现了显著的正相关性.
在孕妇中,MCV显示81%的灵敏度和77%的特异性异常的MMA在MCV切线93.1.1.
在一般人群中,MCV测试在识别异常MMA/tHCY方面表现不佳.

结论:

MCV是一种具有成本效益的工具,用于查无症状孕妇的维生素B12异常.
用MCV进行查可能有助于减少患有B12缺乏症母亲产生的婴儿出现不良神经结果的发生率.
为了优化不同人群的MCV查协议,可能需要进一步的研究.

关键词:

发育延迟的发展延迟.叶酸是什么叶酸是什么叶酸是什么同型半氨酸同型半氨酸平均体质体积的体积.甲基马洛尼的 ccidid 维生素B12 维生素B12 是一种

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