出生时的DNA甲基化和儿童时的侧腔室体积:一个神经成像表观遗传学研究
Mannan Luo1,2, Esther Walton3, Alexander Neumann4
1Department of Psychology, Education and Child Studies, Erasmus University Rotterdam, Rotterdam, The Netherlands.
概括
出生时的DNA甲基化可以预测整个生命中侧腔室体积 (LVV) 的变化. 这种表观遗传标志物显示出理解大脑发育和精神分裂症风险的潜力.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学 是一个
- 发展生物学 发展生物学
背景情况:
- 侧腔室体积 (LVV) 扩大与精神分裂症有关.
- 影响早期LVV发育的生物学因素尚不清楚.
- 在精神分裂症中观察到的DNA甲基化 (DNAm) 改变对神经发育至关重要.
研究的目的:
- 调查新生儿DNA甲基化与儿童LVV之间的关联.
- 检查早期表观遗传修饰是否持续存在,并在以后的生活中与LVV相关.
- 探索DNAm作为LVV和相关神经精神疾病的潜在生物标志物.
主要方法:
- 进行了第一个新生儿DNAm在带血中与儿童LVV进行的第一个全表观基因组关联研究.
- 利用了来自R世代研究 (N=840) 和艾文长度父母与儿童研究 (ALSPAC,N=114) 的数据.
- 采用探针级和甲基化概况得分 (MPS) 方法,分析带血液,儿童外周血液和成人外周血液中的DNAm.
主要成果:
- 在出生时确定了四种CpG (KCTD3,SDCCAG8,GLRX),可能与儿童LVV有关.
- 更广泛的表观遗传特征 (MPS) 显示了与儿童LVV的显著横截面关联以及与成人LVV的潜在关联.
- 个别的顶级CpG点击并没有显示与MPS相同的广泛关联.
结论:
- 有线证据表明,出生时的DNA甲基化可能与不同生命阶段的LVV有关.
- 作为LVV标记物的DNAm的稳定性和可重复性得到了儿童和成人样本MPS预测的支持.
- 需要对更大的队列和纵向数据进行进一步的研究,以澄清DNAm在LVV发育和神经精神病风险中的作用.
更多相关视频
11:19Correlating Gene-specific DNA Methylation Changes with Expression and Transcriptional Activity of Astrocytic KCNJ10 Kir4.1
Published on: September 26, 2015
8.0K
13:11Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain
Published on: July 12, 2012
18.8K
相关概念视频
02:30Genomic Imprinting and Inheritance
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
01:10Nature and Nurture
Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience, such as differences...
01:28Human Genetics
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...