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疲劳对儿童急性淋巴细胞白血病幸存者的认知功能障碍的贡献
Alice Mochon1,2, Sarah Lippé1,2, Maja Krajinovic1,3
1Research Centre, Sainte-Justine University Health Center (SJUHC), Montréal, Québec, Canada.
Pediatric hematology and oncology
|July 20, 2023
概括
儿童急性淋巴细胞白血病 (cALL) 幸存者的晚期影响包括神经认知问题和疲劳. 这项研究发现,疲劳增加显著提高了这些幸存者的认知缺陷的风险.
科学领域:
- 儿科瘤学 儿科瘤学
- 神经心理学 神经心理学
- 长期生存率 长期生存率
背景情况:
- 儿童急性淋巴细胞白血病 (cALL) 幸存者经常经历神经认知缺陷和疲劳等晚期影响.
- 在cALL幸存者中,疲劳和神经认知障碍之间的关系尚不清楚.
研究的目的:
- 在长期cALL幸存者的队列中描述神经认知困难和疲劳.
- 研究疲劳水平与神经认知缺陷风险之间的关联.
主要方法:
- 来自加拿大中心的285名长期cALL幸存者的队列完成了认知测试 (DIVERGT) 和疲劳量表 (PedsQL).
- 使用后勤回归模型来评估基于疲劳水平的认知缺陷风险.
主要成果:
- 31%的幸存者至少表现出一种认知缺陷,主要是工作记忆,精细运动技能和口语流.
- 睡眠/休息疲劳水平高于人口标准.
- 增加的一般性疲劳和睡眠/休息疲劳独立地增加了速度/灵活性,工作记忆和口语流性认知缺陷的风险.
结论:
- 疲劳是儿童急性淋巴细胞白血病幸存者的神经认知缺陷的重要危险因素.
- 管理疲劳可能是缓解这一群体认知问题的关键策略.
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