摄入血汁会改变与心脏代谢生物标志物相关的肠道微生物群的特定细菌
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Updated: Jul 23, 2025
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Murine Fecal Isolation and Microbiota Transplantation
Published on: May 26, 2023
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Telma Angelina Faraldo Corrêa1,2, Eric de Castro Tobaruela1,2, Vinicius Cooper Capetini2,3
1Department of Food and Experimental Nutrition, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Frontiers in microbiology
|July 20, 2023
概括
摩洛汁摄入改善了超重女性的肠道微生物群和心脏代谢健康. 每日摄入增强了短链脂肪酸 (SCFA) 和胰岛素敏感性,在2-4周内观察到好处.
科学领域:
- 营养科学 营养科学
- 微生物组研究 微生物组研究
- 心血管健康 心血管健康
背景情况:
- 血汁含有丰富的生物活性化合物,如黄和酸.
- 这些化合物的健康益处背后的机制需要进一步阐明.
- 肠道微生物群在代谢健康中起着至关重要的作用.
研究的目的:
- 为了研究摩罗汁 (MOJ) 对肠道微生物群组成的影响.
- 评估MOJ对心脏代谢生物标志物和胰岛素抵抗的影响.
- 探索肠道微生物群变化与代谢改善之间的关系.
主要方法:
- 12名超重女性每天服用500毫升MOJ,持续4周.
- 肠道微生物群,短链脂肪酸 (SCFA),心脏代谢生物标志物和HOMA-IR在基线,2周和4周被测量.
- 统计分析发现了微生物变化和生物标志物之间的关联.
主要成果:
- MOJ摄入改变了特定的肠道微生物操作分类学单位 (OTU),但没有改变整体多样性.
- 观察到SCFA (propionic,同黄油酸) 的产量增加.
- 血压,血VCAM-1,禁食葡萄糖,胰岛素水平和HOMA-IR的显著改善.
- 发现了 Bacteroidetes phyla/Prevotella 9 属和心脏代谢生物标志物之间的关联.
- 有益效应在2周后显而易见,其中一些在4周后变得显著.
结论:
- MOJ的摄入量以特定的方式对肠道微生物群组成产生积极影响.
- 消费MOJ可以改善肥胖女性的心脏代谢生物标志物和胰岛素敏感性.
- MOJ摄入的持续时间对于观察显著的健康益处很重要.
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