西尼罗河病毒在西班牙埃克斯特拉马杜拉的人类中出现2020年西尼罗河病毒在西班牙埃克斯特拉马杜拉 2020年西尼罗河病毒在西尼罗河病毒的人类中出现
Alicia Macias1, Paloma Martín2, Mayte Pérez-Olmeda3,4
1Servicios de Microbiología y Medicina Interna, Hospital Don Benito-Villanueva de la Serena, Don Benito, Badajoz, Spain.
Frontiers in cellular and infection microbiology
|July 20, 2023
概括
西班牙在2020年经历了最大的西尼罗河病毒 (WNV) 人类疫情. 这项研究详细介绍了西班牙埃克斯特拉马杜拉首次爆发的WNV疫情,包括临床,诊断和控制方面.
科学领域:
- 流行病学 流行病学
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 西班牙在2020年报告了其最大的人类西尼罗河病毒 (WNV) 爆发,埃克斯特拉马杜拉是主要受影响的地区.
- 埃克斯特拉马杜拉之前在2004年在西班牙报告了第一个本土人类WNV病例,直到2020年才有进一步的病例.
研究的目的:
- 描述了西班牙埃克斯特拉马杜拉首次人类WNV疫情.
- 详细介绍2020年疫情期间实施的临床表现,诊断结果和控制措施.
主要方法:
- 使用分子 (qRT-PCR) 和血清学 (IgM/IgG的ELISA) 方法诊断人类WNV感染.
- 血清,尿液和脑脊液样本被分析;阳性样本对相关的黄病毒 (Usutu,TBE) 进行了测试,并通过中和试验证实.
主要成果:
- 确定了6例WNV感染病例,5例患有神经侵入性疾病,1例患有发烧.
- 样本中没有检测到病毒RNA,但观察到与其他黄病毒的血清交叉反应.
- 记录了所有病例的临床和实验室发现.
结论:
- 2020年在埃斯特雷马杜拉爆发的疫情凸显了加强对WNV和其他新出现的黄斑病毒的监测的必要性.
- 分子和血清诊断方法,以及差异诊断,对于WNV的检测和管理至关重要.
- 持续监测对于早期检测和应对该地区的WNV和其他特有黄斑病毒至关重要.
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