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动脉样硬化和血管化中的细胞外囊泡:来自内皮细胞和血管光滑肌细胞的多功能非编码RNA

Fengyi Yu¹, Yingjie Duan¹, Chongmei Liu²

¹Department of Nephrology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China.

Frontiers in medicine

|July 20, 2023

概括

细胞外囊泡 (EVs) 携带非编码RNAs (ncRNAs),它们介于内皮细胞 (ECs) 和血管光滑肌细胞 (VSMCs) 之间的通信. 本综述探讨了EC-EV和VSMC-EV中涉及动脉样硬化和血管化的ncRNA.

科学领域:

心血管生物学心血管生物学
分子生物学分子生物学
细胞信号传输细胞信号传输

背景情况:

动脉样硬化 (AS) 涉及动脉脂质和化积累.
血管化 (VC),特别是中间动脉化 (MAC),与AS有关,但有不同的机制.
内皮细胞 (ECs) 和血管光滑肌细胞 (VSMCs) 是AS和VC的关键参与者.

研究的目的:

审查EC和VSMC之间交换的细胞外囊泡 (EV) 中的非编码RNA (ncRNA).
阐明这些ncRNAs在AS和VC的发病过程中的作用.
在血管疾病中识别受EV封装的ncRNAs影响的信号通路.

主要方法:

对EC-EV和VSMC-EV中ncRNA研究的文献综述.
对已识别的ncRNAs (miRNAs, lncRNAs, circRNAs) 和它们的功能进行分析.
这些ncRNA介导的AS和VC中涉及的信号通路的总结.

主要成果:

电子细胞作为关键的细胞间信使,在EC和VSMC之间传输ncRNA.
EVs中的特定ncRNAs在AS和VC进展中发挥了重要作用.
在EV中的许多ncRNA在血管疾病中具有功能,这些功能仍需要完全理解.

结论:

通过EV介导的ncRNAs转移是AS和VC期间EC-VSMC通信中的关键机制.
向EV封装的ncRNAs为血管化和动脉样硬化提供了潜在的治疗策略.
需要进一步的研究,以全面了解所有检测到的ncRNAs在血管疾病进展中的功能.

关键词:

动脉样硬化 (AS) 的疾病细胞外囊泡 (EVs) 的产生.非编码RNAs (ncRNAs) 是一种非编码RNA.尿血尿病是什么意思血管化 (VC) 是一种

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