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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Natriuretic Peptides (BNP)
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多发性硬化症中的蛋白质生物标志物

Jun-Soon Kim1,2

  • 1Department of Neurology, Seoul National University Bundang Hospital, Seongnam, Korea.

Encephalitis (Seoul, Korea)
|July 20, 2023
PubMed
概括

本综述确定了血液和脑脊液中的关键蛋白质生物标志物,用于早期多发性硬化症 (MS) 诊断,疾病活动预测和治疗监测. 神经纤维蛋白和酶3样蛋白1显示出对MS治疗的显著潜力.

科学领域:

  • 神经学 神经学
  • 生物化学 生物化学
  • 生物标志物发现发现

背景情况:

  • 多发性硬化症 (MS) 的诊断和管理需要可靠的生物标志物.
  • 目前对MS的诊断和预后工具存在局限性.
  • 体液中的蛋白质生物标志物为改善多发性硬化患者护理提供了潜力.

研究的目的:

  • 审查和阐明MS的血液和脑脊液 (CSF) 中的蛋白质生物标志物.
  • 确定用于早期诊断的生物标志物,疾病活动预测和MS治疗反应监测.
  • 评估特定蛋白质的作用,包括神经丝蛋白 (NFs),GFAP,瘦素,BDNF,CHI3L1,CXCL13和OPN在MS中的作用.

主要方法:

  • 系统审查有关国家蛋白质生物标记物的科学文献.
  • 对研究神经丝蛋白 (NFs),GFAP,瘦素,BDNF,CHI3L1,CXCL13和OPN的研究进行分析.
  • 对MS患者与对照组生物标志物水平的评估以及与疾病参数的相关性.

主要成果:

  • 与对照组相比,在MS患者中观察到高水平的GFAP,素和CHI3L1.
  • 神经纤维蛋白 (NFs) 与多发性硬化症的活动,进展和治疗结果有很强的相关性.
关键词:
生物标志物 生物标志物大脑脊髓液中的脑脊液.中间的丝片是中间的丝片.多发性硬化症是多发性硬化症.

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  • 血液/脑脊髓中CHI3L1预测从临床隔离综合征 (CIS) 转化为确定的MS;CXCL13反映了MS疾病的活动.

    • 结论:

    • 一些蛋白质生物标志物,包括NFs和CHI3L1,显示出早期MS诊断和预后的前景.
    • GFAP,瘦素,BDNF,CHI3L1,CXCL13和OPN在MS病理生理学和进展中都发挥着不同的作用.
    • 需要进一步的研究来确定在MS治疗中常规临床使用的高度敏感和特定的生物标志物.