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作为治疗三阴性乳腺癌的治疗工具的CRISPR/Cas9:从银行到诊所

Prashant Kumar Tiwari¹, Tin-Hsien Ko², Rajni Dubey³

¹Biological and Bio-Computational Lab, Department of Life Sciences, Sharda School of Basic Science and Research, Sharda University, Greater Noida, Uttar Pradesh, India.

Frontiers in molecular biosciences

|July 20, 2023

概括

通过针对关键的调控机制,聚类定期间隔的短平行体重复 (CRISPR) 基因编辑显示了治疗三阴性乳腺癌 (TNBC) 的前景. 对交付方法和AI集成的进一步研究对于临床应用至关重要.

科学领域:

基因组学就是基因组学.
分子生物学分子生物学
癌症研究癌症研究

背景情况:

克里斯普尔-Cas9是一种革命性的基因组编辑工具,可用于疾病治疗.
三重阴性乳腺癌 (TNBC) 存在重大治疗挑战,包括耐药性.
Prokaryotes 中内源的 CRISPR/Cas9 系统提供了防御机制.

研究的目的:

审查CRISPR/Cas9用于TNBC治疗的进展,挑战和前景.
探索CRISPR/Cas9在克服TNBC药物耐药性的潜力.
突出AI和机器学习在增强TNBC的CRISPR/Cas9策略中的作用.

主要方法:

对TNBC中的CRISPR/Cas9应用现有文献的审查.
对各种CRISPR/Cas9传递方法 (物理,病毒,非病毒) 的分析.
讨论在in-vivo基因组编辑的有针对性交付方面的挑战.

主要成果:

基于CRISPR/Cas9的策略可能通过向抗性基因,转录和表观遗传调节来抑制TNBC生长.
存在各种传递系统,但敏感和向的体内生殖方法有限.
人工智能和机器学习的整合可能会提高TNBC治疗中的CRISPR/Cas9疗效.

结论:

克里斯普尔/Cas9对TNBC治疗具有显著的潜力,解决了药物耐药性等关键问题.
克服交付挑战对于将CRISPR/Cas9疗法转化为临床实践至关重要.
整合AI/ML为优化基于CRISPR/Cas9的TNBC疗法提供了一个有希望的途径.

关键词:

这就是CRISPR/Cas9的作用.耐药性和人工智能的人工智能基因编辑基因编辑免疫疗法免疫疗法三重阴性乳腺癌是什么

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