取决于环境的T细胞受体基因谱档案在T大颗粒性淋巴细胞的增殖中
Jorn L J C Assmann1, Elisavet Vlachonikola2, Pieter M Kolijn1
1Laboratory for Medical Immunology, Department of Immunology, Erasmus MC, Rotterdam, Netherlands.
HemaSphere
|July 20, 2023
概括
T细胞大颗粒性淋巴细胞 (T-LGL) 淋巴增殖显示了情境依赖的T细胞受体β基因库. 这些发现有助于在各种临床环境中区分T-LGL,并确定潜在的反应性T-LGL来源.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
背景情况:
- T细胞大粒状淋巴细胞 (T-LGL) 淋巴增殖代表了从多克隆到单克隆的频谱,边界不清楚.
- 这些条件与各种疾病和抗原触发物有关,通常涉及恶性克隆中持续的STAT3激活.
- 了解T细胞受体β (TRB) 基因库对于特征T-LGL异质性至关重要.
研究的目的:
- 研究T-LGL淋巴增殖中TRB基因库的亚克隆结构.
- 为了确定TRB基因谱图模式和临床表现之间的关联.
- 根据临床背景和呈现来区分T-LGL淋巴增殖.
主要方法:
- 下一代测序被用于对27名T-LGL患者的TRB基因库进行分析.
- 分析的重点是确定克隆架构及其与临床数据的相关性.
- 进行了纵向研究,观察时间克隆动态.
主要成果:
- 在T-LGL淋巴增殖中TRB基因库是取决于背景的,在不同的临床环境中观察到不同的克隆结构.
- 单克隆T-LGL细胞,有或没有STAT3突变,可以导致中性衰竭.
- 在频谱的另一端确定了反应性橄克隆T-LGL淋巴增殖.
- 纵向分析揭示了时间动态,这表明T-LGL可能是其他恶性瘤的副现象,可能对瘤抗原有反应.
结论:
- T-LGL 淋巴增殖表现出上下文依赖的 TRB 基因谱图模式.
- 不同的克隆架构与不同的临床环境和表现相关.
- T-LGL细胞可以作为反应现象出现,特别是在其他恶性瘤的背景下.
相关概念视频
T Cell Activation and Clonal Selection
815
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
815
Diversity of Antigen Receptors
641
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
641
Cells of the Adaptive Immune Response
1.0K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
1.0K
T Cell Types and Functions
1.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.1K
Lymphoid Cells and Tissues
1.2K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
1.2K


