在等离子光纤照明下细菌群聚效应的表征
Jang Ah Kim1, Yingwei Hou1, Meysam Keshavarz1,2
1Imperial College London, Institute of Global Health Innovation, The Hamlyn Centre, London, United Kingdom.
Journal of biomedical optics
|July 20, 2023
概括
等离子热电泳 (PTEP) 能够实现粒子群聚,用于诸如药物输送等应用. 这项研究描述了PTEP,揭示了粒子特性如何影响细菌微机器人的行为,并优化了PTEP的未来使用.
科学领域:
- 微流体学和纳米技术
- 生物物理学的生物物理.
- 塑制剂是一种塑制剂.
背景情况:
- 等离子热电泳 (PTEP) 使用等离子微观结构来诱导粒子运动和集体群聚.
- 在粒子操纵和向药物输送方面,PTEP具有潜力,但需要进一步描述.
- 了解PTEP对于实现其全部应用潜力至关重要.
研究的目的:
- 用PTEP来描述各种粒子和细菌细胞的运动和蜂群效应.
- 为了实现基于细菌的微机器人和药物输送系统的合理设计.
- 为了将粒子特性与PTEP诱导的行为相关联.
主要方法:
- 通过双光子聚合制造塑光纤 (POFs) 的制造.
- 使用基于图像的粒子跟踪来描述粒子运动和粒子群.
- 分析时空度变化和与泽塔潜力和粒子形状的相关性.
主要成果:
- PTEP产生的阻力力从数百fN到几十pN.
- 具有更高负泽塔潜力和更光滑形状的细菌 (例如,克莱布西拉肺炎,大肠杆菌) 显示出增强的蜂群.
- 粒子特性显著影响PTEP驱动的群体行为.
结论:
- 基于PTEP的细菌群群的表征行为有助于预测粒子/细胞反应.
- 这项研究有助于合理设计PTEP应用程序.
- 这些发现为实现PTEP在微机器人和药物输送等不同领域的潜力铺平了道路.
相关概念视频
Bacterial Signaling
32.8K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
32.8K
Gene Regulation in Microbial Communities: Quorum Sensing
40
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
40


