与细胞癌相关的副新生脑炎
Yoonhyuk Jang1, SeonDeuk Kim1, Kon Chu1
1Department of Neurology, Seoul National University Hospital, Seoul, Korea.
Encephalitis (Seoul, Korea)
|July 20, 2023
概括
副发性脑炎是一种罕见的自身免疫性疾病,可能与细胞癌 (RCC) 有关. 结合免疫疗法和瘤切除的早期治疗为患有这种罕见的癌症神经学关联的患者提供了最好的结果.
科学领域:
- 神经学 神经学
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 麻性脑炎是一种与潜在瘤相关的自身免疫性疾病.
- 细胞癌 (RCC) 是一种常见的癌,很少与瘤神经综合征有关.
- 这项研究调查了神经瘤脑炎和RCC之间的联系.
研究的目的:
- 为了识别和描述与细胞癌相关的副瘤性脑炎病例.
- 探索该患者队列中的临床表现,诊断结果和治疗结果.
主要方法:
- 确定了一个具有RCC的自身免疫脑炎患者的潜在机构队列.
- 诊断标准包括操作性自身免疫脑炎标准和同时诊断RCC与神经症状.
- 对三个脑炎和RCC患者的病例系列分析.
主要成果:
- 确定了三名脑炎和RCC患者;两名清细胞RCC和一名染色体恐惧RCC.
- 所有患者都出现了边缘脑炎,表现出诸如认知能力下降,记忆障碍或发作等症状.
- 大脑MRI显示,在两个清细胞RCC患者中, mesial叶T2高强度;一个染色恐惧RCC患者没有显著的发现.
- 在RCC发病后一个月内进行早期手术干预与良好的治疗反应相关.
结论:
- 与RCC相关的副发性脑炎通常呈现为边缘脑炎.
- 涉及免疫治疗和瘤切除的治疗可能是有效的.
- 在血清阴性自身免疫脑炎的差异诊断中应考虑RCC.
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