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Updated: Jul 23, 2025

Multi-Modal Home Sleep Monitoring in Older Adults

Multi-Modal Home Sleep Monitoring in Older Adults

Published on: January 26, 2019

在中年后期和老年患有阻塞性睡眠呼吸暂停的成年人中,休息状态功能连接模式发生变化

Guillermo Martinez Villar^1,2, Véronique Daneault¹, Marie-Ève Martineau-Dussault^1,2

¹Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Centre Intégré Universitaire de Santé et de Services Sociaux du Nord de l'Île-de-Montréal, Montréal, QC, Canada.

Frontiers in neurology

|July 20, 2023

概括

阻塞性睡眠呼吸暂停 (OSA) 与记忆区域的大脑连接性降低有关,特别是在认知不受损的老年人中. 这些功能连接性变化可能会在明显的认知衰退之前发生.

科学领域:

神经科学是一个神经科学.
睡眠医学睡眠医学
认知老龄化认知老龄化

背景情况:

阻塞性睡眠呼吸暂停 (OSA) 是认知能力下降的新兴风险因素.
OSA与记忆相关区域的结构性大脑变化有关.
在这些地区,OSA对功能连接 (FC) 的影响尚不清楚,特别是在老年人群中.

研究的目的:

调查默认模式网络 (DMN) 和中间叶 (MTL) 区域之间的OSA严重程度和静止状态FC之间的关联.
探索FC变化是否根据认知状态 (认知无损与认知无损) 不同. 轻度认知障碍 (MCI) 是一种轻度认知障碍.
为了确定是否改变了FC与认知表现有关.

主要方法:

94名老年人 (41%患有MCI) 接受了多睡眠影像,神经心理测试和休息状态fMRI.
一般的线性模型评估了OSA严重性指数 (呼吸暂停-呼吸暂停,氧气脱,微刺激) 和DMN-MTL FC.之间的关系.
部分相关性检查了FC模式,OSA严重程度和认知得分之间的关联,控制年龄,性别和教育.

主要成果:

较高的呼吸暂停-呼吸暂停指数与中部前额叶皮和海马之间,以及海马和后侧带带皮层/前之间较低的FC相关.
这些关联在没有认知障碍的个体中是显著的,但在MCI组中没有.
没有发现FC模式和认知表现之间有显著的关联,也没有发现氧气脱和微刺激指数.

结论:

OSA的严重程度与大脑对记忆至关重要的区域的功能连接性降低有关,并且与阿尔茨海默病有关.
这些连接性改变可能是OSA对大脑影响的早期,临床前标志物.
需要进一步的纵向研究来确定这些FC变化是否预测未来的认知能力下降.

关键词:

老化的老化衰老的老化默认模式网络模式默认模式网络模式在海马体内,海马体中部前额叶皮层中部前额叶皮层中间叶中部叶后侧带状皮层的皮层.静止状态的功能连接.睡眠障碍呼吸睡眠障碍呼吸

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