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在组分水平上早期吸入过敏原敏感化:对阿托皮性荷兰儿童的分析

Lonneke J Landzaat¹, Joyce A M Emons¹, Laura J H Sonneveld¹

¹Division of Pediatric Respiratory Medicine and Allergology, Department of Pediatrics, Erasmus MC University Medical Center, Rotterdam, Netherlands.

Frontiers in allergy

|July 20, 2023

概括

对过敏性鼻炎的敏感化在荷兰的亚托皮儿童中很常见,从婴儿期开始. 家庭灰尘是儿童早期的主要触发因素,强调了早期诊断和管理的必要性.

科学领域:

儿科过敏和免疫学
呼吸系统医学呼吸系统医学
免疫学免疫学免疫学

背景情况:

过敏性鼻炎是一种普遍存在的儿童呼吸道疾病.
对吸入过敏原的敏感性是其发展的一个关键因素.
有限的数据存在于非常年轻的亚托皮儿童的敏感性概况.

研究的目的:

在荷兰的亚托皮性儿童中研究IgE敏感性对吸入过敏原成分的IgE敏感性.
专注于4岁以下儿童过敏性鼻炎的早期发展.
评估敏感性概况的临床相关性.

主要方法:

对243名亚托皮儿童进行了横截面回顾性研究.
多重复合微阵列分析 (ISAC) 用于敏感性分析.
对五种过敏原源 (草,树花粉,高质量菌,猫,狗) 的IgE反应进行分析.

主要成果:

92%的儿童对吸入过敏原产生敏感性.
敏感性从婴儿时期就普遍存在 (87%),在1岁后增加.
家庭灰尘是儿童早期最常见的敏感剂.

结论:

对吸入过敏原的敏感性是常见的,在荷兰的亚托皮儿童中早期发生.
在幼儿中,特定的过敏原分子,如Der f1,Der p1和Fel d1是显著的.
在这个人群中,对过敏性鼻炎的早期评估和治疗至关重要.

关键词:

年龄组年龄组.过敏原是一种过敏原.过敏原组成部分.过敏是一种过敏.吸入过敏原的吸入剂微阵列分析分析的方法鼻炎是一种鼻炎.敏感化敏感化

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