与cuproptosis相关的lncRNAs可以预测甲状腺癌的预后和免疫反应
Yinli Shi1, Pei Sheng1, Ming Guo2
1The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, China.
Frontiers in genetics
|July 20, 2023
概括
这项研究确定了七种与cuproptosis相关的长非编码RNA (lncRNAs),可预测甲状腺癌 (THCA) 存活率. 这些发现可以通过分析瘤免疫力和药物敏感性来改善THCA预后和治疗策略.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 基因组学就是基因组学.
背景情况:
- 甲状腺癌 (THCA) 带来了重大的生存挑战.
- 长非编码RNAs (lncRNAs) 越来越多地被认为是它们在癌症中的作用.
- 细胞亡是一种新型的受调细胞死亡,正在成为癌症进展的一个因素.
研究的目的:
- 开发基于与cuproptosis相关的lncRNAs的THCA预后模型.
- 探索这些lncRNAs,瘤免疫力和THCA中的药物敏感性之间的关联.
- 为了确定THCA的潜在治疗点.
主要方法:
- 利用了THCA的TCGA和GEO数据库中的RNA-Seq和临床数据.
- 使用考克斯回归和LASSO对与cuproptosis相关的lncRNAs构建了一个预后风险模型.
- 进行生物信息学分析,包括PCA,GO,KEGG,ssGSEA,TIDE和TMB评估.
主要成果:
- 一个七个lncRNA签名 (AC108704.1,DIO3OS,AL157388.1,AL138767.3,STARD13-AS,AC008532.1,PLBD1-AS1) 证明了THCA预后的预测有效性.
- 与cuproptosis相关的lncRNAs与免疫细胞透和瘤免疫微环境有显著的联系.
- 具有高瘤突变负担 (TMB) 的高风险患者的生存率降低;低风险患者的TIDE得分更高,表明免疫治疗的反应较差.
结论:
- 与cuproptosis相关的lncRNAs作为THCA预后的潜在生物标志物.
- 鉴定到的lncRNAs提供了关于cuproptosis,免疫力和THCA进展之间的相互作用的见解.
- 这项研究可能会为THCA患者提供个性化的治疗策略.
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