基于基因组变异分析的衰老和衰老得分作为肺腺癌的预后指标和治疗指南
Tao Lin1, Hong Wang2, Ying Liu3
1Department of Thoracic Surgery, Tangshan People's Hospital, Tangshan, China.
Frontiers in genetics
|July 20, 2023
概括
老化和衰老基因对肺腺癌 (LUAD) 有影响. 一个新的得分 (ASRS) 预测患者的生存率和治疗反应,区分免疫疗法和化疗的好处.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 衰老研究研究 衰老研究
背景情况:
- 人们越来越认识到衰老和细胞衰老对癌症发展,进展和治疗反应的作用.
- 与衰老和衰老相关的基因 (ASRG) 对肺腺癌 (LUAD) 的临床结果和治疗策略的具体影响尚不清楚.
研究的目的:
- 开发和验证与衰老和衰老相关的评分系统 (ASRS),使用来自LUAD患者的批量转录组数据.
- 调查ASRS与临床特征,生存结果和LUAD中的瘤微环境 (TME) 免疫模式之间的关联.
- 评估ASRS在LUAD患者治疗疗效方面的预测价值.
主要方法:
- 来自22个LUAD数据集的大量转录组数据的整合,包括3,243个样本.
- 开发一个与衰老和衰老相关的评分系统 (ASRS).
- 统计分析以将ASRS与瘤阶段,病理等级,生存指标 (总体,无疾病,无复发) 和TME免疫概况相关联.
主要成果:
- 在LUAD患者中,较高的ASRS得分与晚期瘤阶段和病理等级有显著的关联.
- 增加的ASRS与较短的整体存活率,无病存活率和无复发存活率相关.
- 在LUAD瘤微环境中,ASRS与免疫模式有明显的关联.
- ASRS有效地预测了免疫疗法和化疗的差异反应,低的ASRS有利于免疫疗法,高的ASRS有利于化疗.
结论:
- 开发的ASRS是一种新的生物标志物,反映了LUAD的衰老和衰老特征.
- ASRS是不良预后的重要预测因素,并影响肺腺癌患者的治疗结果.
- 通过预测LUAD中免疫疗法与化疗的反应,ASRS有可能指导个性化治疗策略.
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