数据对于确定南亚死产的原因是有用的
Robert L Goldenberg1, Kay Hwang2, Sarah Saleem3
1Columbia University, New York, New York, USA.
概括
在印度和巴基斯坦,胎盘病理和母体病史对于确定死产的原因是最有用的. 胎儿检查,包括肺组织学和PCR检测,也为识别常见和可预防的死胎提供了有价值的数据.
科学领域:
- 围产儿医学 围产儿医学
- 病理学 病理学 病理学
- 遗传学 是一个遗传学.
背景情况:
- 在低收入和中等收入国家,特别是南亚,死产仍然是一个重大挑战.
- 准确确定死产的原因对于实施有效的预防策略至关重要.
研究的目的:
- 评估各种数据源的诊断实用性,以确定印度和巴基斯坦的死胎病因.
- 确定在资源有限的环境中进行死胎调查的最有信息的方法.
主要方法:
- 关于印度和巴基斯坦医院200例胎儿死亡的前性观察研究.
- 用于75种病原体的胎盘评估,内部器官的最小侵入性组织采样 (MITS) 和聚合酶链反应 (PCR).
- 评估了母亲病史,胎盘和胎儿体重,各种器官组织学和PCR结果的有用性.
主要成果:
- 胎盘病理学是最有用的诊断工具.
- 胎盘和胎儿体重的比较在近一半的病例 (44.5%和48.5%) 中具有信息意义.
- 肺组织学 (42.5%) 和胎盘,大脑和带血的PCR也很有价值,尽管不如组织学那么一致.
结论:
- 母亲的临床病史,胎盘组织学和胎儿检查是死胎调查中最有信息的组成部分.
- 建议的方法包括肺组织学和多重PCR血液和大脑/CSF的常见和可预防的死产原因.
- 承认识别遗传和罕见异常的局限性,但强调确认最频繁和可预防的死产病因.
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