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在患有口腔面部缺陷的儿童中,唾液微生物组和喘风险
I-Lun Chen1,2, Faye Huang3, Sung-Chou Li4
1Department of Pediatrics, College of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, Kaohsiung, Taiwan.
Pediatric pulmonology
|July 20, 2023
概括
嘴巴裂口 (CP) 的婴儿患喘的风险更高. 患有口唇裂 (CLP) 的婴儿口腔微生物群的差异可能会导致这种风险.
科学领域:
- 儿科肺病学 儿科肺病学
- 口腔和牙面部外科手术
- 微生物组研究 微生物组研究
背景情况:
- 先天性口腔面部缺陷,如裂唇 (CL),裂 palatus (CP),裂唇和裂 palatus (CLP),使呼吸道暴露于口腔微生物.
- 这种暴露可能会影响呼吸道粘膜免疫的发展.
研究的目的:
- 分析患有CL,CP和CLP的婴儿喘发生情况.
- 为了研究这些婴儿的唾液微生物组合.
- 评估口腔微生物群与儿童喘风险之间的关联.
主要方法:
- 用多变量回归分析对患者数据 (2004-2015年) 的回顾分析.
- 未来的唾液微生物组分析 (2016-2020年) 使用下一代测序在健康和CLP婴儿.
- 由ICD代码和治疗标准定义的喘诊断.
主要成果:
- 与CL和CLP组相比,在CP患者中观察到更高的喘发病率 (aOR:5.644).
- 在产后1个月和6个月的CLP婴儿和健康婴儿之间发现了唾液微生物组物种组成的显著差异.
结论:
- 患有口腔面部缺陷的儿童,特别是CP,面临患喘的风险较高.
- 早期的口腔微生物群可能在与这些疾病相关的喘风险增加中发挥作用.
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