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预测双卵巢刺激 (DuoStim) 后获得的卵细胞总数
A La Marca1, V Donno1, M Longo1
1Department of Medical and Surgical Sciences of the Mother, Children, and Adults, University of Modena and Reggio Emilia, Modena, Italy.
Human reproduction (Oxford, England)
|July 20, 2023
概括
抗穆勒尔激素 (AMH) 水平可以预测在IVF中的DuoStim协议期间检索的卵细胞数量. 较高的AMH值与更多的卵细胞相关,有助于患者咨询.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在体外受精 (IVF)
- 卵巢刺激协议 卵巢刺激协议
背景情况:
- 该DuoStim协议,涉及两个连续的卵巢刺激在单个周期内,用于患者的卵巢反应较差和生育能力的保护.
- 抗穆勒尔激素 (AMH) 是卵巢储备的公认标志物,可以预测刺激反应.
研究的目的:
- 调查AMH在预测DuoStim协议后检索的卵细胞数量的诊断性能.
- 建立AMH作为在DuoStim周期中量化卵巢反应的临床工具.
主要方法:
- 对116名接受试管婴儿治疗的患者进行了回顾性观察性研究.
- 血清AMH水平与DuoStim后检索的卵细胞数量之间的相关性分析.
- 使用C统计评估的诊断性能.
主要成果:
- 血清AMH水平与DuoStim (R=0.61,P<0.0001) 后检索的卵细胞总数有显著的正相关性.
- 每0.25 ng/mL的基底AMH增加对应于一个额外的卵细胞.
- 虽然在第一次和第二次刺激之间,总卵细胞产量显著增加,但成熟卵细胞数量没有显著差异.
结论:
- 血清AMH是一种可靠而简单的临床工具,用于预测DuoStim周期中的卵巢反应.
- AMH测量可以帮助定量预测检索的卵细胞数量,改善对IVF结果的患者咨询.
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