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相关概念视频

High-Performance Liquid Chromatography: Types of Detectors01:15

High-Performance Liquid Chromatography: Types of Detectors

621
The role of the detectors in High-Performance Liquid Chromatography (HPLC) is to analyze the solutes as they exit from the chromatographic column. The detector recognizes the solute's property and generates corresponding electrical signals, which are converted into a readable graph of the detector's response versus elution time called a chromatogram at the computer. There are several types of HPLC detectors, each with its own advantages and limitations, depending on the analyte...
621
Gas Chromatography: Overview of Detectors01:13

Gas Chromatography: Overview of Detectors

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Detectors in gas chromatography (GC) help identify and quantify the components of a mixture by translating chemical properties into measurable signals, which are displayed on a chromatogram. Detectors can be categorized into two main types: destructive and non-destructive.
A non-destructive detector allows a sample to be analyzed without altering or consuming it, meaning the sample can be collected after detection for further analysis. Examples include thermal conductivity detectors and...
628
Gas Chromatography: Types of Detectors-II01:19

Gas Chromatography: Types of Detectors-II

420
In gas chromatography, different detectors are employed to meet specific analytical needs. These detectors are often categorized based on their detection mechanisms and the types of compounds they are best suited to analyze. Thermal Conductivity Detectors (TCD), Flame Ionization Detectors (FID), and Electron Capture Detectors (ECD) represent common categories, each with unique operating principles and applications. However, beyond these, several other detectors are designed for more specialized...
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相关实验视频

Updated: Jul 23, 2025

PTR-ToF-MS Coupled with an Automated Sampling System and Tailored Data Analysis for Food Studies: Bioprocess Monitoring, Screening and Nose-space Analysis
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PTR-ToF-MS Coupled with an Automated Sampling System and Tailored Data Analysis for Food Studies: Bioprocess Monitoring, Screening and Nose-space Analysis

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下游加工中的传感器和化学计量.

Astrid Dürauer1, Alois Jungbauer1,2, Theresa Scharl3

  • 1Institute of Bioprocessing Science and Engineering, University of Natural Resources and Life Sciences, Vienna, Austria.

Biotechnology and bioengineering
|July 20, 2023
PubMed
概括

生物制药制造正在向自动化,自主化的过程过渡. 集成软传感器和预测化学测量可以实时监测和控制强大的生物制造.

科学领域:

  • 生物制药制造业 生物制药制造业
  • 过程控制 过程控制
  • 化学测量 化学测量 化学测量

背景情况:

  • 生物制药行业传统上以批量模式运作,因为严格的法规和依赖离线质量控制.
  • 关键的产品质量属性包括数量,纯度,功效,以及没有偶然的剂和生物负担.
  • 一次性使用技术和综合生物处理等新兴趋势正在塑造生物制造的未来.

研究的目的:

  • 审查自动化和自主化生物处理的步骤,重点关注监测和控制策略.
  • 探索用于现代过程控制的软传感器和预测化学测量的集成.
  • 证明这些概念在下游生物制药加工中的应用.

主要方法:

  • 审查当前的生物处理实践和监管举措 (过程分析技术,设计质量,连续集成制造).
  • 使用软传感器逐步整合实时监控的概念.
  • 应用统计工具,如多变量统计和神经网络,用于模型训练.

主要成果:

  • 软传感器为将实时监控集成到生物处理中提供了一种可行的方法.
  • 预测化学测量,结合软传感器,可以增强过程控制.
  • 在下游加工步骤中成功应用,如染色学和膜过.
关键词:
连续的综合生物制造.机器学习是机器学习.过程控制过程控制实时释放实时释放.

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Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry UPLC-MS
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结论:

  • 自动化和自主生物处理是生物制药行业可实现的目标.
  • 软传感器和预测化学测量是实时释放和强大的生物制造的关键推动因素.
  • 这些技术的逐步实施将导致高度预测和高效的生物制造系统.