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免疫检查点抑制剂反应和毒性的生物标志物:挑战和机遇

Rachel S Goodman1, Seungyeon Jung1, Justin M Balko2

  • 1Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

Immunological reviews
|July 20, 2023
PubMed
概括

免疫检查点抑制剂提供了新的癌症治疗方法,但预测反应和管理副作用仍然具有挑战性. 研究重点是生物标志物,以改善治疗选择和减少毒性.

关键词:
在MHC-II中,MHC-II是最常见的.生物标志物 生物标志物免疫检查点抑制剂 免疫检查点抑制剂与免疫相关的不良事件.免疫疗法 免疫疗法瘤突变负担的突变负担

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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