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重新审视脑微发作:检测,原因和临床相关性

Jiannan Huang¹, Geert Jan Biessels², Frank-Erik de Leeuw³

¹Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.

International journal of stroke : official journal of the International Stroke Society

|July 20, 2023

概括

大脑微心脏病发作 (CMIs) 是通过MRI检测到的小脑病变. 最近的进展改善了CMI检测,揭示了与血管疾病,心脏病和认知衰退等负面神经结果的联系.

科学领域:

神经学神经学
神经成像是一种神经成像.
病理学病理学病理学

背景情况:

大脑微型心脏病发作 (CMIs) 是小的缺血性病变,通常无法通过尸检检测到,但可以通过MRI看到.
先进的神经成像技术,如扩散加权成像 (DWI) 检测偶然的小DWI阳性病变 (ISDPLs),可以代表CMIs.

研究的目的:

审查最近 (2017年以来) 在理解脑微发作 (CMI) 的进展.
涵盖CMI检测,原因,风险因素,MRI发现和临床影响.

主要方法:

对皮层CMI和ISDPL的最新文献的审查.
专注于新的神经病理学和神经成像检测方法.
分析病因因素,风险因素,MRI相关性和临床后果.

主要成果:

冠状动脉感染有多种原因,包括小/大血管疾病和心脏疾病 (例如心房动).
机制包括血管重塑,炎症,血脑屏障问题,低 perfusion 和微栓塞.
脑膜炎与认知能力下降,中风风险增加,死亡率和神经行为障碍有关.

结论:

改进的检测方法提高了CMI的理解.
CMI显著影响大脑功能,连接性,并导致缩.
进一步的研究对于管理CMI相关的神经缺陷至关重要.

关键词:

大脑微型心脏病发作这就是为什么MRI是MRI.大脑小血管疾病是大脑小血管疾病.痴呆症痴呆症是一种痴呆症.神经成像是一种神经成像.神经病理学神经病理学

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