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Zhan-Peng Ge1, Yuan Gao1, Yan Zhang1

  • 1State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China.

The Journal of organic chemistry
|July 20, 2023
PubMed
概括

研究人员发现了来自Strobocalyx chunii的新型germacranolide sesquiterpene乳. 一种化合物,斯特罗诺利德C,在体外显示出对HL-60细胞系具有显著的细胞毒性活性.

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Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...