里奇队的人数超过了他们! 未来的REACH和动物号码的未来
Costanza Rovida1, Francois Busquet1,2, Marcel Leist1,3
1Center for Alternatives to Animal Testing (CAAT) - Europe, University of Konstanz, Germany.
ALTEX
|July 20, 2023
概括
欧盟的REACH法规已经使用了数百万只动物进行毒性测试,未来的修订可能会增加这一数字. 这凸显了迫切需要减少化学安全评估中的动物试验.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 监管科学 监管科学
背景情况:
- 欧盟的REACH法规规定,动物试验是化学安全的最后手段.
- 尽管有这种原则,但在REACH下,对各种毒性终点发生了大量的动物使用.
- 替代方法的拒绝率,如ECHA的阅读,表明当前合规性检查的局限性.
研究的目的:
- 量化到2022年12月之前用于REACH测试的动物数量.
- 估计由于正在进行的合规性检查和即将到来的REACH修正案,动物试验的潜在增加.
- 通过提供有关当前和预计动物使用的数据,为REACH修订的辩论提供信息.
主要方法:
- 对REACH登记档案报告的动物试验数据的分析.
- 对特定毒性终点 (生殖,发育,重复剂量) 的动物使用的估计.
- 基于REACH拟议修正案和合规性检查结果,对未来动物使用的预测.
主要成果:
- 到2022年12月,大约有290万只动物被用于生殖,发育和重复剂量毒性测试.
- 目前,另外130万只动物正在接受测试,预计将有更多的动物接受测试.
- 估计表明,用于其他终点的动物数量为0.6至3.2百万,以及2022年REACH修正案的额外动物数量为3.6至7.0百万.
- 建议对REACH的修改可能需要1600万到2600万的动物试验.
结论:
- 目前的REACH实施导致了大量的动物使用,这与"最后手段"原则相悖.
- 即将到来的REACH修订和正在进行的合规性检查可能会大大增加动物试验.
- 在REACH中,迫切关注减少动物使用至关重要,特别是考虑到拟议的监管变更.
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