在体外评估血凝固反应对四种医疗级聚氨聚合物的体外评估
Lan Nguyen1, Li-Chong Xu2, Eric Yeager2
1Department of Biochemistry and Molecular Biology, Gettysburg College, Gettysburg, PA, USA.
Journal of biomaterials applications
|July 20, 2023
概括
为心血管设备寻找新的聚氨 (PU) 生物材料至关重要. 这项研究发现,包括BioSpan 2F和CarboSil 20 80A在内的几个PU显示出有希望的血液兼容性和低FXII接触激活.
科学领域:
- 生物材料科学 生物材料科学
- 心血管工程 心血管工程
- 聚合物化学 聚合物化学
背景情况:
- 分段聚氨 (PU) 由于其生物相容性和机械强度,对心血管设备至关重要.
- 停止使用PU Biospan MS/0.4需要确定合适的替代PU生物材料.
- 血液相容性是评估心脏生物材料的关键因素.
研究的目的:
- 描述四种医疗级PU的表面特性:生物跨度MS/0.4,生物跨度S,生物跨度2F和CarboSil 20 80A.
- 用牛和人类血液评估这些PUs的血凝固反应.
- 评估FXII接触激活的潜在血栓发生性.
主要方法:
- 表面分析包括化学,地形,微相分离和湿度.
- 采用牛和人类血进行体外凝血测定.
- 染色体测试用于测量XII因子 (FXII) 接触激活.
主要成果:
- 生物 Span 2F 呈现出高含量和最低的表面自由能量;其他 PU 含有.
- 与聚钢相比,所有测试的PU都证明了血液凝固的改善.
- 在PU生物材料中没有观察到凝血时间或FXII接触激活的显著差异.
结论:
- 评估的医疗级聚氨显示出有利的血液兼容性概况.
- 这些PU表现出较低的FXII接触激活,这表明血栓形成潜力降低.
- 生物Span 2F和CarboSil 20 80A是心血管应用的潜在替代品.
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