在儿科心脏外科手术中低剂量输血和 perfusion
Alok Kumar1, Gurpinder S Ghotra2, Sangeeth Raj1
1Department of Anaesthesia and Critical Care, Army Hospital (Research and Referral), Delhi Cantt, New Delhi, India.
Annals of cardiac anaesthesia
|July 20, 2023
概括
低剂量的血管压素在儿科心脏手术中改善了血液动力学,但没有改善功能. 这种血管压缩剂输液显示出较少并发症的趋势,尽管在统计学上并不显著.
科学领域:
- 儿科心脏手术 儿科心脏手术
- 关键护理医学 关键护理医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 先天性心脏手术带来了绕道术后脏和心脏功能障碍的风险.
- 低剂量的压缩已经在成人心脏手术中证明了益处.
研究的目的:
- 评估低剂量输血压素输注在接受式心脏手术的儿科患者的血液动力学和效应.
- 评估对 perfusion,功能和炎症标志物的影响.
主要方法:
- 一项前性随机受控研究,涉及55名患有先天性心脏病的儿科患者.
- 在式心脏手术期间低剂量输血压素输注与安慰剂的比较.
- 监测近红外光谱,血清NGAL,IL6,IL8和血液动力学参数.
主要成果:
- 压缩剂组显示显著更高的透静血压和心脏指数.
- 炎症标志物 (IL6,IL8) 在术后升高,但在各组之间相似.
- 随着血管压素的使用,没有观察到 perfusion 或功能的显著改善.
结论:
- 低剂量的血管压素改善了血液动力学,并表明在儿科心脏手术中减少并发症的趋势.
- 在这个患者群体中,压素对功能或整体结果没有显著的益处.
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