在COVID-19患者的呈现时,白细胞体积,导电性和散射
M Ormen1, O G Doruk1, H Gozgoz1
1Department of Medical Biochemistry, Dokuz Eylül University Faculty of Medicine, Turkey.
Nigerian journal of clinical practice
|July 20, 2023
概括
COVID-19感染改变了白细胞 (白细胞) 的形态. 中性粒细胞百分比增加和淋巴细胞和单细胞的显著体积变化与严重的COVID-19疾病进展相关.
科学领域:
- 血液学 血液学 血液学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- COVID-19与白细胞计数的变化有关.
- 在COVID-19患者中观察到循环血液细胞的形态异常.
研究的目的:
- 调查白细胞形态和功能与COVID-19严重程度之间的关系.
- 分析与疾病分层相关的细胞种群数据.
主要方法:
- 分析了来自130名COVID-19患者的血液样本,按疾病严重程度分层 (轻度,中度,严重).
- 在 Beckman Coulter LH-780 血液学分析仪上利用了体积,导电性,散射 (VCS) 技术.
- 统计分析包括Kruskal-Wallis测试与邦费罗尼校正.
主要成果:
- 严重的COVID-19患者与轻度和中度组相比,中性粒细胞数量和中性粒细胞/淋巴细胞比率增加.
- 随着疾病的严重程度,观察到中性粒细胞体积和导电性分散的显著变化.
- 在严重的COVID-19患者中,淋巴细胞和单细胞的体积增加明显高于轻度和中度的组.
结论:
- COVID-19 感染诱导白细胞细胞群数据的显著变化.
- 淋巴细胞和单细胞的体积变化与COVID-19疾病严重程度直接相关.
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