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Updated: Jul 23, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

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开发基于palbociclib的新型CDK4/6抑制剂,探索守门员背后的后口袋

Lina Li1, Fengquan Chen2, Mengzhe Li2

  • 1Department of Pharmacy, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, People's Republic of China.

Investigational new drugs
|July 20, 2023
PubMed
概括

与palbociclib.m相比,一种新型化合物17m显示了对乳腺癌细胞的增强CDK4/6抑制和抗增殖作用. 这种选择性抑制剂表现出改善的代谢稳定性,提供了一个有前途的新疗法途径.

关键词:
这是一种抗癌药物.这是一种CDK4/6抑制剂.细胞循环停止 细胞循环停止药物设计策略 药物设计策略

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Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries

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