血管细胞控制中枢神经系统组织模仿系统中的神经共同定位和突触连接
SongHo Moon1, Yuzuru Ito2,3
1Faculty of Life and Environmental Sciences (Bioindustrial Sciences), University of Tsukuba, 1-1-1 Tenno-Dai, Tsukuba, Ibaraki, 305-8972, Japan.
Human cell
|July 20, 2023
概括
中枢神经系统 (CNS) 血管系对于发展神经网络至关重要. 这项研究强调了内皮细胞和细胞周细胞如何支持神经组织工程中的突触形成和稳定.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 组织工程是组织工程.
背景情况:
- 标准化突触形成仍然是神经组织分化的一个挑战.
- 中枢神经系统 (CNS) 中的神经网络的发展与血管血管生成密切相关.
研究的目的:
- 研究血管系在神经形态发生和突触稳定中的作用.
- 在中枢神经系统的背景下,了解神经元-星细胞-血管相互作用.
主要方法:
- 使用干细胞,星细胞和血管细胞在基于原的细胞外基质 (ECM) 中开发共同培养模块.
- 分析由血管组件诱导的细胞共定位效应和突触改善.
主要成果:
- 内皮细胞表现出一种神经系统的同定位效应.
- 细胞在共同培养模型中显著改善了突触连接.
- 包括PDGF,BDNF,IGF和WNT/BMP在内的通路的升调在增强的突触条件下观察到,涉及神经素.
结论:
- 中枢神经系统血管系统的完整性对于建立功能神经元网络至关重要.
- 血管细胞在突触的稳定和连接中起着关键作用.
更多相关视频
相关概念视频
Nervous Tissue: Glial Cells
3.2K
Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial...
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial...
3.2K
Glial Cells
87.7K
Overview
87.7K
Neurogenesis and Regeneration of Nervous Tissue
863
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
863


