代谢异常的患病率及其与儿童喘症状控制的关联
Ketan Kumar1, Rakesh Lodha2, Kana Ram Jat1
1Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
Indian journal of pediatrics
|July 20, 2023
概括
超过40%的患有喘的儿童患有胰岛素抵抗 (IR),这种代谢异常与较差的喘症状控制有关. 这些发现凸显了儿童喘患者的代谢健康监测的重要性.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 呼吸系统医学 呼吸系统医学
- 代谢健康 代谢健康
背景情况:
- 喘是儿童常见的慢性呼吸道疾病.
- 代谢异常,如胰岛素抵抗 (IR),失脂血症和代谢综合征 (MS) 在各种慢性疾病中越来越多地被认可.
- 这些代谢因素与儿童群体中喘控制之间的关系需要进一步研究.
研究的目的:
- 确定患有喘的10-15岁儿童中IR,失脂症和MS的患病率.
- 评估这些代谢异常与喘症状控制之间的关联.
- 研究喘儿童的代谢参数和肺功能之间的联系.
主要方法:
- 一项涉及83名被诊断患有喘的儿童的横截面研究.
- 使用全球喘倡议 (GINA) 准则对喘症状控制的评估.
- 测量空腹血葡萄糖,血清胰岛素和脂质概况;计算恒常状态模型评估-胰岛素抵抗 (HOMA-IR).
- 进行了螺旋计,以评估肺功能.
主要成果:
- 在被研究的儿童中,IR的患病率为42.3%.
- 在小比例的参与者中观察到高甘油,总胆固醇和LDL胆固醇.
- 低HDL胆固醇在80.7%的儿童中普遍存在.
- 存在IR,血清胰岛素升高和甘油三与喘控制较差有关,独立于BMI.
- 在调整身高后,在代谢参数和肺功能之间没有发现显著的关联.
结论:
- 在患有喘的儿童中,发现胰岛素抵抗的高患病率 (42.3%).
- 血清胰岛素,甘油三和IR存在的升高与这一儿科队列中喘控制的降低有关.
- 这些发现强调了对患有喘的儿童进行代谢查的必要性,以改善整体管理.
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