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在无法解释的慢性咳患者的发声过程中,喉体感觉运动皮层的非典型激活
Stephanie Misono1, Jiapeng Xu2, Jinseok Oh2,3,4
1Department of Otolaryngology, Head and Neck Surgery, University of Minnesota, Minneapolis.
JAMA otolaryngology-- head & neck surgery
|July 20, 2023
概括
患有慢性咳的人在发声过程中,感觉运动皮质中的大脑活动减少. 这表明慢性咳会影响喉区域的神经处理,即使在不活跃咳时也是如此.
科学领域:
- 神经科学是一个神经科学.
- 呼吸系统医学 呼吸系统医学
- 临床神经学 临床神经学
背景情况:
- 无法解释的慢性咳显著损害生活质量.
- 了解慢性咳的神经机制对于开发有效治疗方法至关重要.
- 外围和中央神经过程都涉及,但尚未完全理解.
研究的目的:
- 为了调查慢性咳患者在自愿发声期间喉感觉运动皮质的神经处理异常.
- 为了比较慢性咳患者和健康对照患者在发声过程中的脑电图 (EEG) 活动.
主要方法:
- 跨截面研究设计,涉及患有慢性咳的参与者和年龄相匹配的健康对照.
- 在受控环境中,在自愿发声时记录的脑电图 (EEG) 信号.
- 对喉感觉运动皮质 (θ,α,β波段) 事件相关的光谱扰动和连贯性的分析.
主要成果:
- 与对照人群相比,患有慢性咳的参与者在发声期间在感觉运动皮层上的 θ,α和β频段中与运动相关的脱同步显著减少.
- 这表明在慢性咳组的声乐任务期间,大脑振荡活动的抑制较弱或不存在.
- 这些发现表明,慢性咳患者的感觉运动皮质活动发生变化.
结论:
- 慢性咳与发声期间感觉运动皮质活动的改变有关,即使没有咳.
- 这项研究强调了慢性咳对与喉运动控制相关的中枢神经处理的影响.
- 这些发现对于理解病理生理学和设计慢性咳的未来治疗策略具有重要意义.
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