在严重的缺氧期间,可可黄可以保护认知功能,大脑氧化和精神疲劳,在严重的缺氧期间保护认知功能,大脑氧化和精神疲劳
Peter M Bloomfield1, James P Fisher2, David M Shaw3
1Exercise Neurometabolism Laboratory, University of Auckland, Auckland, New Zealand.
Journal of applied physiology (Bethesda, Md. : 1985)
|July 20, 2023
概括
可可黄素增强认知能力,减少严重缺氧期间的疲劳,提供神经保护. 在不受控制的呼吸过程中观察到这些好处,但在维持二氧化碳水平时没有.
科学领域:
- 神经科学是一个神经科学.
- 人体生理学 人体生理学
- 营养科学 营养科学
背景情况:
- 缺氧或低氧水平会损害认知功能和大脑氧化.
- 可可黄因其抗氧化和血管扩张性质而闻名.
- 了解缓解缺氧认知影响的干预措施对于高空活动和某些医疗条件至关重要.
研究的目的:
- 为了研究可可黄对认知表现和脑氧化在急性严重缺氧期间的影响.
- 为了确定可可黄是否提供神经保护,防止缺氧引起的认知缺陷.
- 探索呼吸条件 (poikilocapnic与isocapnic缺氧) 对弗拉万诺的疗效的影响.
主要方法:
- 与12名参与者进行的安慰剂控制,双盲试验.
- 在测试前90分钟内摄入可可黄醇 (15mg·kg-1) 或安慰剂.
- 认知任务在正常氧和严重缺氧 (相当于5500米) 状态下进行,碳二氧化物水平不受控制 (poikilocapnic) 或受控制 (isocapnic).
- 使用功能近红外光谱学 (fNIRS) 测量的大脑氧化率.
主要成果:
- 波基洛卡普尼克缺氧损害了整体认知能力,但与安慰剂相比,可可黄醇提高了4%的性能.
- 可可黄醇减弱了在poikilocapnic hypoxia期间因缺氧引起的大脑氧化减少.
- 随着安慰剂的使用,主体疲劳显著增加,但在poikilocapnic缺氧期间,flavanols没有显著增加.
- 异皮性缺氧也会影响认知,但可可黄在这些条件下没有提供显著的认知益处.
- 可可黄素在诺摩西亚期间和在异性缺氧期间进一步降低了反应时间.
结论:
- 可可黄具有神经保护作用,在严重,不受控制的缺氧期间改善认知和大脑氧化.
- 在normoxia中观察到的可可黄的认知益处似乎在严重的缺氧期间持续存在.
- 在异皮性缺氧期间缺乏认知改善表明可可黄和二氧化碳水平之间的潜在相互作用.
- 需要进一步的研究来阐明可可黄在缺氧期间的神经保护作用的机制和最佳条件.
相关概念视频
01:23Hypoxia
1.1K
Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
1.1K
01:27CNS Depressants: Alcohol and Nicotine
256
Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
256
01:27Oxygen Transport in the Blood
2.8K
Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...
2.8K
01:21Fatigue
208
Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
208
01:24Muscle Recovery and Fatigue
2.2K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
2.2K
01:30Cognitive Development During Adulthood
159
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
159