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Updated: Jul 22, 2025

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使用生理学基础的药物动力学建模软件教药物处置:GastroPlus作为教育工具

Noam Morningstar-Kywi1,2, Denise N Morris2, Rebecca M Romero1

  • 1Department of Pharmacology and Pharmaceutical Sciences, University of Southern California Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, Los Angeles, California, United States.

Advances in physiology education
|July 20, 2023
PubMed
概括

使用生理学基础药理动力学 (PBPK) 建模软件的积极学习有效地教授科学原理和软件操作. 这种方法增强了对药物开发的PBPK建模的理解.

关键词:
在 PBPK 建模中使用 PBPK 模型.生物制药公司教育教育教育教育的教育.药物动力学 药物动力学教学教学教学教学教学教学教学教学教学教学

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Drug transporters are critical in drug absorption, distribution, and excretion processes. They should be included in physiological-based pharmacokinetic (PBPK) models, which help predict human drug disposition. However, predicting this is challenging during drug development, especially when liver transport is involved. However, with a realistic representation of body transport processes, an accurate model may be possible.
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