怀孕期间使用的性饮食是否会影响子女的神经系统发育?─FTIR显微光谱研究
Marzena Rugiel1, Zuzanna Setkowicz-Janeczko2, Wojciech Kosiek2
1Faculty of Physics and Applied Computer Science, AGH University of Krakow, Krakow 30-059, Poland.
ACS chemical neuroscience
|July 20, 2023
概括
怀孕期间的性饮食 (KD) 在新生大鼠中显示出最小的脑部生化变化. 然而,年长的后代表现出脂质代谢障碍和大脑结构的改变,这表明产前KD暴露的潜在风险.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生化学
- 发展生物学 发展生物学
背景情况:
- 抗发作药物对神经系统发育有风险.
- 对于患有的孕妇,需要采用性饮食 (KD) 等替代疗法.
- 产前KD暴露对后代大脑发育的安全性需要调查.
研究的目的:
- 为了确定后代大脑生物分子组成在产前暴露于性饮食 (KD) 后的潜在异常.
- 分析怀孕期间母体KD消费对雄性Wistar老鼠后代发育中的大脑的影响.
主要方法:
- 在怀孕期间,雌性Wistar大鼠被食KD或标准饮食.
- 男子后代在出生后的第二天,第6天和第14天被研究.
- 富里埃变换红外显微镜分析了大脑的宏分子组成 (蛋白质,脂质,酸盐,胆固醇) 和结构.
主要成果:
- 产前KD暴露通常不会在2日和6天大的后代中引起大脑生化异常.
- 一个例外是2天大老鼠白质和皮质中酸盐化合物的增加.
- 14天大的后代显示碳化合物增加,脂质减少,脂质结构变化,白质表面积减少 (内部囊).
结论:
- 产前KD暴露似乎对早期大脑发育是安全的,但可能会在以后引发生化和结构变化.
- 在年长的后代中观察到的变化表明脂质代谢发生变化以及体升高的潜在影响.
- 进一步的研究对于了解产前KD暴露对后代神经发育的长期后果至关重要.
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