在产前人类大脑中绘制microRNA表达量的特征位置意味着miR-1908-5p表达在双相情感障碍和其他与大脑相关的特征
Carolina C Toste1, Michael C O'Donovan1, Nicholas J Bray1,2
1Centre for Neuropsychiatric Genetics & Genomics, Division of Psychological Medicine & Clinical Neurosciences, Cardiff University, Cardiff CF10 4HQ, United Kingdom.
Human molecular genetics
|July 20, 2023
概括
在产前大脑中与microRNA (miRNA) 表达相关的常见遗传变异可能会增加双极性障碍的风险. 改变产前miRNA表达可能是神经精神疾病的早期神经发育风险因素.
科学领域:
- 遗传学 是一个遗传学.
- 神经科学是一个神经科学.
- 分子生物学分子生物学
背景情况:
- 微RNAs (miRNAs) 是基因表达的关键调节者.
- 在早期神经发育过程中,miRNAs起着重要的作用.
- 遗传变异可以影响miRNA表达水平.
研究的目的:
- 为了识别与产前人类大脑中改变miRNA表达相关的常见遗传变异.
- 调查产前miRNA表达在双相情感障碍和其他与大脑有关的特征风险中的作用.
主要方法:
- 在112个基因型胎儿的胎儿大脑组织上进行了小RNA测序.
- 确定了成熟miRNA的表达定量特征位点 (eQTL).
- 这些发现与大脑疾病的全基因组关联研究 (GWAS) 数据相结合.
主要成果:
- 在产前大脑中发现了30个成熟的miRNA的高保证性eQTL.
- 增加miR-1908-5p的产前表达被认为是双相情感障碍的风险机制.
- 与miR-1908-5p表达相关的遗传变异也与抑郁症状,易怒,小脑体积和睡眠时间有关.
结论:
- 在早期发育过程中改变miRNA表达可能会影响对神经精神疾病的易感性.
- 这项研究表明,双相情感障碍的早期神经发育风险机制涉及miR-1908-5p.
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