血糖控制不良和胎盘功能障碍的标志物与糖尿病怀孕中循环胎儿微化学性增加相关
Heidi E Fjeldstad1, Daniel P Jacobsen2, Guro M Johnsen2
1Faculty of Medicine, University of Oslo, Norway; Division of Obstetrics and Gynaecology, Oslo University Hospital, Oslo, Norway.
Journal of reproductive immunology
|July 20, 2023
概括
在糖尿病怀孕中,胎儿微化学性 (FMc) 随着葡萄糖控制不良和胎盘功能障碍而增加. 这表明FMC可能与糖尿病并发症和未来心血管疾病风险有关.
科学领域:
- 生殖免疫学 生殖免疫学
- 孕产妇和胎儿的医学
- 内分泌学 在内分泌学.
背景情况:
- 胎儿微化学 (FMc),胎儿细胞转移到母亲,与妊娠并发症有关.
- 糖尿病 (DM) 与胎盘功能障碍有关,但其对FMC的影响尚不清楚.
研究的目的:
- 研究糖尿病怀孕 (孕前和孕期DM) 中循环的FMC,血糖控制和胎盘功能障碍标志物之间的关联.
主要方法:
- 在122个患有DM的怀孕中使用PCR对母亲血液的量化FMc.
- 分析了FMc水平,HbA1c,口服葡萄糖耐受性测试,可溶性fms类氨酸激酶-1 (sFlt-1) 和出生体重百分点之间的相关性.
主要成果:
- 在孕期DM中,高FMC与更高的HbA1c和sFlt-1水平相关.
- 在妊娠期的DM中,增加的FMC与异常的葡萄糖耐受性测试和非正常的出生体重有关.
结论:
- 胎儿微化学与糖尿病怀孕中血糖控制不良和胎盘功能障碍相关.
- 需要进一步的研究来确定FMc是否有助于孕前风险或长期孕产妇心血管疾病.
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