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根据NHANES生物年龄指数,MS患者的衰老加速
Annalise E Miner1, Jennifer H Yang1, Revere P Kinkel1
1Department of Neurosciences, University of California, San Diego, United States.
Multiple sclerosis and related disorders
|July 20, 2023
概括
多发性硬化症 (MS) 患者与他们的时间年龄相比,表现出加速的生物衰老. NHANES生物年龄指数 (BAI) 与MS残疾相关,特别是通过符号数字模式测试 (SDMT) 测量的认知功能.
科学领域:
- 老年病学和神经病学
- 生物标志物发现和验证
背景情况:
- 时间学年龄与多发性硬化症 (MS) 的残疾进展有关.
- 通过像NHANES生物年龄指数 (BAI) 这样的多标志物指数评估的生物年龄,可以更精确地了解衰老路径和MS严重程度.
- 正常衰老和加速衰老都可能对MS的发展产生负面影响.
研究的目的:
- 为了确定NHANES BAI是否使用临床上可访问的措施,反映了MS加速衰老.
- 调查NHANES BAI与MS患者残疾指标之间的相关性.
主要方法:
- 一项前性,横截面病例控制试点研究招募了51名多发性硬化症患者和38名年龄相似的健康对照.
- 纳恩斯BAI的计算使用了包括血压,肺功能 (FEV1) 和各种血液标记物 (肌素,CRP,BUN,白蛋白,ALP,胆固醇,CMV IgG,HbA1c) 在内的组件.
- 统计分析涉及斯皮尔曼相关性和多变量线性回归来评估BAI与MS结果的关联.
主要成果:
- 多发性硬化患者的平均BAI大约比他们的时间年龄大1.4年.
- BAI显示了与认知功能 (符号数字模式测试,SDMT) 和流动性 (定时25英尺步行,T25FW) 的显著相关性.
- 在多变量分析中,BAI的5年增长与SDMT分数下降1.2个点有关.
结论:
- 多发性硬化患者的生物衰老超过了他们的年龄,而对照组显示相反的趋势.
- 在这项试点研究中,NHANES BAI成为MS生物年龄变异的潜在标志物,显示出与SDMT表现的最强相关性.
- 需要进一步的研究来验证NHANES BAI作为评估MS老化相关因素的临床工具.
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