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相关概念视频

Lateralization01:28

Lateralization

366
Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.
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Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
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在多发性硬化症的thalamic不对称性.

Neda Ramezani1, Fariba Davanian2, Saba Naghavi3

  • 1Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Center for Translational Neuroscience, Isfahan University of Medical Sciences, Isfahan, Iran.

Multiple sclerosis and related disorders
|July 20, 2023
PubMed
概括

多发性硬化症 (MS) 中的thalamic不对称性与疾病进展和亚型有关. 健康的个体比MS患者表现出较少的thalamic不对称性,在复发缓解的MS和二次渐进的MS之间观察到差异.

关键词:
不对称的不对称性缩性缩症 缩性缩症大脑的不对称性计算机辅助的计算机辅助.图像处理 图像处理磁共振成像技术 磁共振成像技术多发性硬化症是多发性硬化症.甲状腺的不对称性泰拉姆斯 泰拉姆斯 泰拉姆斯

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科学领域:

  • 神经成像是一种神经成像.
  • 神经学 神经学
  • 医学研究 医学研究

背景情况:

  • 多发性硬化症 (MS) 是一种慢性神经炎症疾病,影响中枢神经系统.
  • 脑MRI发现,包括不对称性,与使人虚弱的MS症状有关.
  • thalamic不对称性是了解多发性硬化病理学的一个关键研究领域.

研究的目的:

  • 为了研究和比较MS患者的胸膜不对称性.
  • 探讨thalamic不对称性与其他MRI和MS的临床发现之间的关系.
  • 在MS亚型和健康对照中区分thalamic不对称模式.

主要方法:

  • 这是一项涉及83名复发缓解性多发性硬化症 (RRMS),43名二次进展性多发性硬化症 (SPMS) 患者和89名健康对照者的横截面研究.
  • 计算内,灰质,白质,病变和胸膜体积的计算.
  • 评估甲状腺不对称指数 (TAI),9洞测试 (9-HPT) 和扩展残疾状况尺度 (EDSS).

主要成果:

  • 在健康受试者中,正常化整体乳头体积高于在RRMS和SPMS患者中.
  • 在RRMS和SPMS患者中,thalamic不对称指数 (TAI) 显著不同 (p=0.011).
  • 与RRMS (p<0.001) 和SPMS (p<0.001) 患者相比,健康人群的绝对TAI明显较低,SPMS与RRMS (p=0.037) 的绝对TAI更高.

结论:

  • 在正常化整体乳头体积和MS亚型之间存在关系.
  • thalamic不对称指数与MS的疾病进展相关.
  • thalamic不对称性与多发性硬化症的疾病进展和亚型变异有关.