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Updated: Jul 22, 2025

Large Scale Non-targeted Metabolomic Profiling of Serum by Ultra Performance Liquid Chromatography-Mass Spectrometry UPLC-MS
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样本分析的顺序如何影响LC-MS生物分析期间的矩阵效应?

Elżbieta Gniazdowska1, Joanna Giebułtowicz2, Piotr J Rudzki3

  • 1Łukasiewicz Research Network - Industrial Chemistry Institute, Pharmaceutical Analysis Laboratory, 8 Rydygiera, 01-793 Warsaw, Poland; Department of Drug Chemistry, Doctoral School, Medical University of Warsaw, 61 Żwirki i Wigury, 02-091 Warsaw, Poland.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
|July 20, 2023
PubMed
概括

样本分析的顺序显著影响生物分析方法中的矩阵效应变异性. 交叉分析方案比块方案更敏感,用于检测矩阵效应,这对于可靠的药物开发至关重要.

关键词:
生物分析方法验证化学测量 化学测量 化学测量这就是LC-MS.脂血性血中的血.矩阵效应是一个矩阵效应.矩阵因子是一个矩阵因子.脂酸是一种脂酸.

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