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维生素D与早期慢性病之间的关系中的性别差异:基于人口的研究
Ting-An Yang1, Jau-Yuan Chen2, Chieh-An Lin3
1Department of Family Medicine, Chang-Gung Memorial Hospital, Linkou Branch, Taoyuan City 333423, Taiwan; Department of Family Medicine, New Taipei Municipal TuCheng Hospital (Built and Operated by Chang Gung Medical Foundation), New Taipei City 236017, Taiwan.
Nutrition research (New York, N.Y.)
|July 20, 2023
概括
维生素D缺乏 (VDD) 在早期慢性病 (CKD) 中很常见. 这项研究发现,VDD与中国男性的早期CKD有很强的联系,这表明该群体需要进行常规的维生素D查.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
背景情况:
- 维生素D缺乏 (VDD) 在晚期慢性病 (CKD) 中很普遍.
- 在早期CKD (1-3阶段) 中VDD的作用仍然不太清楚.
- 病的进展可能受维生素D状态的影响.
研究的目的:
- 调查血清25-基维生素D [25(OH) D]水平与早期CKD (1-3阶段) 之间的关联.
- 评估中国人口中早期CKD的VDD患病率.
- 确定VDD是否是早期CKD的风险因素,特别是在男性中.
主要方法:
- 一项涉及中国3142个人的横截面研究.
- 测量了血清中的25 ((OH) D度.
- 分析了25 ((OH) D水平与1-3阶段的CKD之间的关联,并对潜在的混因素进行了调整.
主要成果:
- 在5.6%的男性和25.33%的女性中观察到维生素D缺乏 (VDD).
- 在两种性别中,血清25(OH) D度和CKD阶段之间发现了显著的反向关联.
- 在男性中,VDD与1-3阶段的CKD有很强的关联 (调整后OR,15.84;P<.001),但在女性中没有.
结论:
- 维生素D缺乏与研究中中国人口的早期慢性病有关.
- 早期CKD的男性显示出与维生素D缺乏特别强烈的关联.
- 对于被诊断患有早期CKD的个人,特别是男性,建议对维生素D状况进行例行评估.
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