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预测活产的可能性:一个客观和用户友好的胚胎细胞分级系统

Maria Carme Pons¹, Beatriz Carrasco¹, Natalia Rives²

¹Dexeus Mujer- Hospital Universitari Dexeus, Reproductive Medicine Service, Gran, Via Carles III, 71-75. 08028 Barcelona, Spain.

Reproductive biomedicine online

|July 20, 2023

概括

一个新的分级系统客观地对第5天的胚胎细胞进行排名,以确定活产的可能性. 托菲克多德的等级是最重要的预测因素,其次是扩张度.

科学领域:

生殖医学生殖医学
胚胎学胚胎学
在体外受精过程中受精.

背景情况:

胚胎细胞分级对于预测体外受精成功至关重要.
当前的分级系统可能缺乏客观性和用户友好性.
为了可靠的胚胎选择,需要进行标准化评估.

研究的目的:

开发一个客观和用户友好的分级系统,用于第5天的胚胎囊.
根据其实现活产的可能性对囊胞进行排名.
确定可预测怀孕结果的关键形态参数.

主要方法:

对1044个第5天芽细胞囊 (2017-2019) 的回顾性多中心研究.
胚胎囊扩张的形态和形态测量评估,皮和内部细胞质量质量.
后勤回归和决策树分析,以确定活产的预测变量.

主要成果:

已确立的胚胎囊扩张 (≥165微米) 和体细胞数量 (A级:≥14,B级:11-13,C级:≤10) 的切断点.
第三天的胚胎质量没有预测胚胎植入或活产在囊胚阶段.
托菲克托德等级显著预测了活产的可能性 (A级与C级:OR 1.95;B级与C级:OR 1.71).
皮质等级是主要的预测因素,其次是扩张度.

结论:

一个新的目标分级系统为第5天的胚胎囊是可行的.
该系统标准化了囊胚细胞评估,以改善临床应用.
这种方法可以在全球范围内采用,以提高试管婴儿成功率.

关键词:

试管婴儿-ICSI结果胚胎细胞囊中的胚胎囊.胚胎选择胚胎选择分级系统分级系统分级系统.单个胚胎转移是一个胚胎转移.

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