电子烟可能会损害舌头乳头和味蕾. 补充维生素C和E可以逆转这种损伤吗?
Yasmine M Tolba1, Samia S Omar1, Amel R El Hak1
1Faculty of Dentistry, Alexandria University, Egypt.
Life sciences
|July 20, 2023
概括
电子烟 (EC) 和尼古丁会损害味蕾,而EC会造成更严重的影响. 维生素C和维生素E提供了一定程度的保护,但无法完全逆转EC引起的语言乳头损伤.
科学领域:
- 历史学 历史学 历史学
- 口腔病理学 口腔病理学
- 毒理学 毒理学 毒理学
背景情况:
- 电子烟 (EC) 液体会影响舌头的乳头,特别是味蕾.
- 尼古丁是EC液体中已知的成分,具有潜在的不良影响.
- 研究维生素等保护剂对于理解EC毒性至关重要.
研究的目的:
- 从组织学上评估EC液体对老鼠的舌膜和味蕾的影响.
- 为了比较EC液体与纯尼古丁管理的效果.
- 评估维生素C和维生素E在减轻EC引起的组织学变化的潜力.
主要方法:
- 40只雄性大鼠被分为五组:对照组,EC液体,EC液体加维生素C和E,尼古丁和尼古丁加维生素C和E.
- 关于EC液体和尼古丁的剂量为0.75mg/kg.
- 测量包括质素表面积和味蕾与真菌状乳头上皮质表面积的比例.
主要成果:
- EC和尼古丁组显示味蕾扭曲,味蕾与上皮表面积比率显著下降 (p<0.05).
- 接触EC导致了异常的上皮层分层.
- 维生素C和维生素E的使用部分保留了组织学特征,但EC仍然造成了显著的味蕾损伤.
结论:
- 电子烟液体会对语言乳头和味蕾造成显著的损伤,无论尼古丁是否存在.
- 维生素C和维生素E对语言粘膜表现出一些保护作用.
- 电子烟对口腔组织的不良影响是复杂的,不仅仅归因于尼古丁.
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