在风湿性心房动中,在对心肌置换后,用于转换和维持鼻节律的弗莱卡因化
Umesh Tripathi1, Aditya Kapoor1, Surendra Kumar Agarwal2
1Department of Cardiology, Sanjay Gandhi PGIMS, Lucknow, 226014, India.
Indian heart journal
|July 20, 2023
概括
口服弗莱卡尼尼德有效地恢复了心脏节律正常的风湿性心房动患者在中枢置换后. 这种治疗改善了生活质量,并且耐受性很好,这表明它是手术后AF管理的安全选择.
科学领域:
- 心脏病学 心脏病学
- 电力生理学 电力生理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 在许多患者中,心房动 (AF) 在心心膜更换 (MVR) 后仍然存在.
- 弗莱卡因是一种潜在的抗心律失常药物,但由于这些患者对结构性心脏病的担忧,其使用受到限制.
研究的目的:
- 评估口服弗莱卡尼尼德的安全性和有效性,以实现和维持慢性风湿性AF后MVR患者的鼻节律 (SR).
主要方法:
- 口服弗莱卡尼尼德给了25名患有MVR后慢性风湿性AF的患者.
- 患者在出院后接受了弗莱卡尼德和β-阻断剂/diltiazem.
- 非转换者在24小时和4周后接受了电动心脏转换.
主要成果:
- 单次口服弗莱卡尼尼德剂量使24%的患者转化为SR;84%的患者在24小时内实现SR,包括通过心脏转换转化的人.
- 在6个月后,SR在69.5%的患者中维持了93.10毫克的平均flekainide剂量.
- 在SR的患者表现出改善的功能状态,生活质量和显著更高的左心房 (LA) 应变.
结论:
- 口服弗莱卡尼尼德是一种安全有效的治疗方法,用于MVR后的风湿性AF患者.
- 在大多数患者中,SR的维持得到了改善,LA菌株值得到了改善.
- 需要进一步的研究来证实这些发现.
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