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Updated: Jul 22, 2025

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

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开发含有环素的延长释放配方,基于生理学基础的生物制药建模和生物等效安全空间

Everton Miranda Dos Santos1, Humberto Gomes Ferraz2, Michele Georges Issa2

  • 1Department of Pharmaceutical Sciences, Institute of Environmental, Chemical and Pharmaceutical Sciences, Universidade Federal de São Paulo, UNIFESP, Rua São Nicolau, 210, Centro, Diadema, 09913-030, SP, Brazil.

Journal of pharmaceutical sciences
|July 20, 2023
PubMed
概括

基于生理学的生物制药建模 (PBBM) 和生物等价安全空间有助于开发延长释放 (ER) 环素配方. 一种ER迷你平板药物配方实现了虚拟生物等价性,证明了这些方法对ER产品的有用性.

关键词:
生物等效安全空间安全空间循环aprine 的使用情况.解散 解散 解散 是一个过程.IVIVR IVIVR 在线视频美国的 PBBM PBBM

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Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles07:32

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Pharmaceutical equivalents, by definition, are drug products with the same active ingredient in the same quantities, encapsulated in identical dosage forms, and intended for the same administration routes. These pharmaceutical equivalents are deemed bioequivalent if the bioavailability of the active entity in the drug preparations is similar. Moreover, pharmaceutical equivalents demonstrating bioequivalence are also regarded as therapeutically equivalent. This means that when used as directed,...
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Pharmacokinetic models utilize mathematical analysis to achieve a detailed quantitative understanding of a drug's life cycle within the body. They are instrumental in simulating a drug's pharmacokinetic parameters, predicting drug concentrations over time, optimizing dosage regimens, linking concentrations with pharmacologic activity, and estimating potential toxicity.
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Drug transporters are critical in drug absorption, distribution, and excretion processes. They should be included in physiological-based pharmacokinetic (PBPK) models, which help predict human drug disposition. However, predicting this is challenging during drug development, especially when liver transport is involved. However, with a realistic representation of body transport processes, an accurate model may be possible.
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