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尾状细胞的功能活动调解了幼儿时期的微观结构变化与高代谢综合征得分之间的关系

Pei Huang¹, Mya Thway Tint¹, Marissa Lee¹

¹Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore.

|July 20, 2023

概括

儿童尾状微观结构预测了以后的功能活动,这完全介绍了早期大脑变化和代谢综合征得分之间的联系. 这突出了早期大脑发育的原因.

科学领域:

神经科学是一个神经科学.
发展生物学发展生物学
儿科儿科儿科

背景情况:

儿童代谢综合征是未来心血管疾病的危险因素.
尾状核在代谢综合征风险中的作用需要进一步研究.
了解结构性和功能性大脑测量之间的相互作用至关重要.

研究的目的:

调查尾状核测量与儿童代谢综合征得分之间的关联.
检查尾状体的功能和结构神经成像数据之间的关系.
探索大脑测量和抑制控制对代谢综合征风险的影响.

主要方法:

长度出生队列研究利用4.5,6.0和7.5年的神经成像数据.
评估代谢综合征得分在8.0年.
采用皮尔森相关性,线性回归和中介分析,将尾状分数异位变异 (FA),低频波动的分数幅度 (fALFF) 和抑制控制与代谢综合征得分联系起来.

主要成果:

在4.5岁时,左尾状骨的微分异型 (FA) 与代谢综合征得分相关.
7.5岁左右尾巴的低频波动 (fALFF) 分数幅度也与代谢综合征得分相关.
7.5岁的fALFF完全调解了4.5岁的FA和代谢综合征得分之间的关系;抑制控制没有调解这种关系.

结论:

幼儿期尾状微观结构 (4.5岁) 预测了以后的功能活动 (7.5岁).
这种后期的功能活动完全调解了早期微观结构变化与8岁代谢综合征风险之间的关联.
研究结果强调了早期大脑发育在代谢健康轨迹中的关键作用.

关键词:

尾巴状的尾巴状的尾巴状的分数异构的分数异构性.抑制性控制是一种抑制性控制.代谢综合征是代谢综合征.在 rsfMRI 中使用.

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