为草甘及其配方绘制致癌物的关键特征:系统性审查
Iemaan Rana1, Patton K Nguyen1, Gabrielle Rigutto1
1Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA, United States.
Chemosphere
|July 20, 2023
概括
草甘及其配方显示出强有力的机械证据,表明其致癌性,特别是基因毒性和内分泌干扰. 这加强了其作为可能的人类致癌物质的分类,并确定了淋巴发育的潜在途径.
科学领域:
- 毒理学 毒理学 毒理学
- 致癌的发生是致癌的产生.
- 分子生物学分子生物学
背景情况:
- 2015年,草甘被IARC归类为可能的人类致癌物 (2A组).
- 从那时起,许多关于草甘及其配方 (GBF) 的研究已经出现.
- 致癌物的十个关键特征 (KC) 方法为评估癌症危险识别提供了一个框架.
研究的目的:
- 评估体内,体外和体外机理学研究,以证实与草甘/GBF暴露有关的十种致癌物KC.
- 评估支持草甘被归类为可能的人类致癌物质的机制证据.
主要方法:
- 按照PRISMA指南,对已发表的文献进行系统审查和元分析 (PubMed).
- 包括暴露于草甘/GBF的人类和哺乳动物模型的体内,体外和体外研究.
- 采用R用于证据的强度和十个KC的质量评估的数据提取和分析.
主要成果:
- 强有力的证据发现了KC2 (基因毒性),KC4 (脱质),KC5 (氧化应激),KC6 (表观遗传变化) 和KC8 (内分泌干扰).
- 对KC1 (基因组不稳定性) 和KC3 (细胞能量的放松调节) 确定了有限的证据.
- 深入的分析揭示了基因毒性和内分泌干扰的一致,高质量的证据,配方显示的效果比单独的草甘更强.
结论:
- 这些发现加强了机械学证据,将草甘归类为可能的人类致癌物.
- 对人类癌症的关联提供了生物学合理性,例如非霍奇金淋巴瘤.
- 提出了一种可能导致淋巴发育的途径,涉及分子相互作用和关键事件.
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