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David Wertheim¹, Beverley Coldwell², Lisa Miyashita³

¹Faculty of Engineering, Computing and the Environment, Kingston University, Surrey KT1 2EE, UK.

The Science of the total environment

|July 20, 2023

概括

来自拉帕尔马的火山灰.

科学领域:

环境科学环境科学
毒理学毒理学毒理学
材料科学材料科学材料科学

背景情况:

火山爆发,如2021年古布雷哈事件,释放灰尘颗粒.
以前的研究将火山灰与不良健康影响联系起来,但机制尚不清楚.
粒子形状会影响细胞相互作用和潜在的毒性.

研究的目的:

研究拉帕尔马火山灰的3D结构和元素组成.
评估火山颗粒对培养的人类肺细胞的影响.
确定火山灰特性与肺炎球菌粘附之间的关系.

主要方法:

使用共聚焦显微镜对PM10和较小颗粒进行3D成像.
扫描电子显微镜 (SEM) 用X射线分析进行元素组成.
对A549肺细胞进行剂量反应实验,以测量肺炎球菌粘附.

主要成果:

一些火山灰颗粒呈现出尖,角形的3D结构.
元素分析揭示了含,和铁的酸盐颗粒.
暴露于火山粒子增加了肺炎球菌对肺细胞的附着性.

结论:

来自拉帕尔马的火山灰含有具有潜在有害元素组成的酸盐颗粒.
尖的粒子形态可能会导致不良的健康影响.
肺炎球菌粘附度的增加表明,灰暴露后出现呼吸系统问题的机制.

关键词:

A549上皮细胞上皮细胞同焦点显微镜的共聚焦显微镜能量分散式X射线 (EDX) 微分析扫描电子显微镜扫描电子显微镜火山灰颗粒是火山灰的颗粒.

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