有氧运动训练对社区中依赖甲基的人的认知功能和肠道微生物群的影响
Yuping Zhu1, Jiang Zhu1, Gang Song1
1Key Lab of Physical Fitness Evaluation and Motor Function Monitoring, College of Physical Education, Southwest University, Chongqing, 400715, China.
Physiology & behavior
|July 20, 2023
概括
有氧运动训练可以改善依赖甲基胺 (MA) 的人的认知功能. 这种增强与肠道微生物群组成和相关代谢途径的有益变化有关,提供了一个新的治疗途径.
科学领域:
- 神经科学和肠道微生物组研究
- 运动生理学和康复
背景情况:
- 甲基胺 (MA) 的依赖会显著损害认知功能,包括工作记忆和抑制.
- 人们越来越认识到肠道微生物群在调节大脑功能和行为的作用,但它对MA依赖个体认知恢复的具体影响尚未得到充分研究.
研究的目的:
- 研究有氧运动训练对MA依赖个体认知功能的影响.
- 阐明涉及肠道微生物群组成和代谢途径在运动诱导认知增强中的潜在机制.
主要方法:
- 64名依赖MA的个体被随机分配到有氧运动训练组 (DK) 或常规康复组 (CK) 八周.
- 认知功能 (工作记忆,抑制) 用Stroop和Go/NoGo范式进行评估.
- 通过高通量测序分析了肠道微生物组成.
主要成果:
- 与CK组相比,有氧运动训练在DK组显著改善了工作记忆和抑制能力 (P <0.05).
- 在DK组中,有益细菌 (Lactobacillus, Lactococcus lactis, Prevotellaceae, Ruminococcaceae) 的水平增加,有害细菌 (Desulfovibrio, Akkermansia) 的水平降低.
- 在DK组中观察到代谢途径的显著变化,包括d-glutaralate和d-galactate降解以及alanine,aspartate和谷氨酸代谢.
结论:
- 有氧运动训练有效地提高了依赖MA的个体的认知功能,抵消了因MA引起的缺陷.
- 肠道微生物群和相关代谢途径的调节似乎是这群人体中运动介导的认知改善的关键机制.
- 研究结果表明,一种潜在的治疗策略是将运动和微生物群向干预措施结合起来,用于MA成恢复.
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