在易患瘤的肝脏微环境的免疫利基中的脂质代谢
Jintian Chen1, Thomas T H Chan1, Jingying Zhou1
1School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong 999077, SAR, P.R. China.
Journal of leukocyte biology
|July 20, 2023
概括
针对肝脏中的脂质代谢可以重新编程免疫抑制瘤微环境. 这种方法显示出在肝转移和晚期肝癌中增强免疫疗法有效性的潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 代谢途径 代谢途径
- 在瘤学瘤学.
背景情况:
- 肝脏是主要瘤和转移的常见场所,晚期肝癌患者对免疫治疗的反应不佳.
- 肝脏的免疫微环境在肝脏瘤发生,转移和抗癌治疗的抵抗方面至关重要.
- 脂质代谢的改变与非酒精性脂肪性肝病和肝癌的发展有关,影响免疫和树皮细胞功能.
结论:
- 准脂质代谢是一个有希望的治疗途径来治疗肝癌.
- 调节肝脏的免疫代谢状态可以提高免疫检查点抑制剂的疗效.
- 组合疗法有潜力治疗转移的晚期肝癌.
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