[静脉血栓塞栓症和乳腺癌] 这种疾病
Benjamin Crichi1, Emilie Moati2, Carlotta Cacciatore1
1Assistance publique-Hôpitaux de Paris, hôpital Saint-Louis, service de médecine interne, Paris, France.
Bulletin du cancer
|July 20, 2023
概括
患有乳腺癌的女性面临着明显更高的静脉血栓栓塞 (VTE) 风险,这是主要的死亡原因. 危险因素包括年龄,肥胖和癌症治疗,如化疗和激素治疗.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
背景情况:
- 乳腺癌是女性中最常见的癌症.
- 与对照组相比,患有乳腺癌的患者患静脉血栓栓塞 (VTE) 的风险增加了四倍.
- 静脉瘤瘤是癌症患者死亡的主要原因,也是死亡的独立预测因素.
研究的目的:
- 在乳腺癌患者中审查VTE的风险因素.
- 讨论与各种乳腺癌治疗相关的VTE风险.
- 概述目前对该群体的VTE预防的建议.
主要方法:
- 关于乳腺癌患者风险因素和VTE发病率的文献综述.
- 分析与特定疗法相关的VTE风险:塔莫西芬,芳酶抑制剂和CDK4/6抑制剂.
- 检查目前用于血栓预防的临床实践指南.
主要成果:
- 关键的静脉瘤风险因素包括晚年,肥胖,疾病阶段,中央静脉导管和癌症治疗.
- 激素治疗 (塔莫西芬) 在前6个月内显著增加了静脉瘤风险,可能长达2年.
- 循环素依赖性激酶4/6抑制剂与大约6%的VTE率有关.
结论:
- 对于接受化疗或激素治疗的门诊癌症患者,不建议进行例行血栓预防.
- 对血栓预防治疗的风险/益处比率的个性化评估至关重要.
- 多学科讨论应指导乳腺癌患者的静脉瘤预防策略.
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