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Updated: Jul 22, 2025

In Vitro Analysis of E3 Ubiquitin Ligase Function
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由 UBE2L3 泛素结合酶和 HECT E3 酶转移的 IL-1β 循环限制了炎症

Vishwas Mishra1, Anna Crespo-Puig1, Callum McCarthy1

  • 1Medical Research Council Centre for Molecular Bacteriology & Infection, Department of Infectious Disease, Imperial College London, London, UK.

Nature communications
|July 20, 2023
PubMed
概括

UBE2L3,TRIP12和AREL1 E3连接酶控制了白内素-1β (IL-1β) 前体的稳定性. 在小鼠中删除Ube2l3会导致IL-1β的过度产生,炎症和疾病.

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